文献类型：期刊文献

中文题名：耐力运动对高脂膳食大鼠肝脏瘦素受体、IGF-1和IGFBP-3的影响

英文题名：Effects of endurance exercise on leptin receptor,insulin growth factor-1 and insulin growth factor binding protein-3 in liver of hyperlipid-diet rats

作者：邵月[1]

机构：[1]河南省政法管理干部学院体育部

第一机构：河南财经政法大学体育部（系）

年份：2010

卷号：30

期号：10

起止页码：1364-1365

中文期刊名：中国老年学杂志

外文期刊名：Chinese Journal of Gerontology

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金资助项目(No.30871212);教育部2007年度新世纪人才支持计划(No.790013P8);上海市浦江人才计划(No.44038470);2009年度河南省政法管理干部学院重大课题(No.2009-y2k-020)

语种：中文

中文关键词：耐力运动;高脂膳食;IGF-1;IGFBP-3;瘦素受体

外文关键词：Endurance exercise; Hyperlipid diet; IGF-1; IGFBP-3; Leptin receptor

摘要：目的探讨耐力运动对高脂膳食大鼠肝脏胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)和瘦素受体含量的影响。方法 20只大鼠随机分为安静组(H组)和耐力训练组(R组),每组10只,训练8w;采用Bedford训练方案,耐力训练相当于65%VO2max;末次训练后24h各组大鼠安静状态下处死,取肝脏。采用酶联免疫吸附测试(定量)法分别测定肝脏中IGF-1、IGFBP-3和瘦素受体含量。结果 R组IGF-1蛋白含量显著高于H组(P<0.05);R组IGFBP-3蛋白含量显著高于H组(P<0.05);两组IGFBP-3/IGF-1比值没有显著性差异;R组瘦素受体含量非常显著高于H组(P<0.01)。结论耐力运动能够促进高脂膳食大鼠IGF-1、IGFBP-3和瘦素受体的表达,是一种十分有效的治疗方式,对于促进机体健康有一定意义。
Objective To investigate the effects of endurance exercise on insulin growth factor-1（IGF-1）and insulin growth factor binding protein-3（IGFBP-3）and leptin receptor in hyperlipid-diet rats＇liver.Methods 20 male SD rats were randomly divided into quietness group（H）and endurance exercise group（R）（n=10）.8 weeks training was carried.Bedford＇s exercise program was adopted.Exercise intensity of R was seemly equal to 65%VO2max.After the last training 24 h,the rats were killed and liver was taken out.The contents of IGF-1,IGFBP-3 and leptin receptor were measured by ELISA.Results The contents of IGF-1,IGFBP-3 and leptin receptor in R group were higher than those of H group（P〈0.05,P〈0.01）.There was no difference in IGFBP-3/IGF-1 between R and H groups.Conclusions Endurance exercise can promote the expressions of IGF-1,IGFBP-3 and leptin receptor,is a very effective therapeutic method and is important for health.