文献类型：期刊文献

英文题名：The relationship between medication literacy and skin adverse reactions in non-small-cell lung cancer patients undergoing targeted EGFR-TKI therapy

作者：Du, Ruofei[1,2,3];Yang, Huashan[1];Zhou, Huiyue[1];Ma, Lixia[4];Getu, Mikiyas Amare[1];Chen, Changying[2];Wang, Tao[1,5,6,7]

第一作者：Du, Ruofei

通讯作者：Wang, T[1];Chen, CY[2]

机构：[1]Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China;[2]Zhengzhou Univ, Dept Qual Control, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China;[3]Zhengzhou Univ, Acad Med Sci, Zhengzhou 450001, Peoples R China;[4]Henan Univ Econ & Law, Sch Stat, Zhengzhou 450046, Peoples R China;[5]Telethon Kids Inst, Perth, WA 6872, Australia;[6]Univ Western Australia, Sch Med, Perth, WA 6872, Australia;[7]Peoples Hosp Hebi, Hebi 458010, Peoples R China

第一机构：Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China

通讯机构：[1]corresponding author), Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China;[2]corresponding author), Zhengzhou Univ, Dept Qual Control, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.

年份：2022

卷号：22

期号：1

外文期刊名：BMC CANCER

收录：;Scopus(收录号：2-s2.0-85129556570);WOS:【SCI-EXPANDED(收录号:WOS:000790201500002)】；

基金：1. China Postdoctoral Science Foundation in 2018: (2018M630839) 2. The National Natural Science Foundation of China (No.81773175) The funding bodies played no role in the design of the study, the collection, analysis and interpretation of the data or the writing of the manuscript.

语种：英文

外文关键词：Medication literacy; Skin adverse drug reactions; NSCLC; EGFR-TKI; Targeted therapy

摘要：Background High medication literacy is the basis of rational medication application and is essential for the management of severe adverse drug reactions. The objective of the present study was to assess the level of medication literacy and determine the association between medication literacy and skin adverse drug reactions in non-small-cell lung cancer (NSCLC) patients undergoing targeted epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy. Methods This is a cross-sectional study conducted from May to September 2020. In total, 296 NSCLC patients undergoing targeted EGFR-TKI therapy were recruited from hospitals in Henan, China. Structured questionnaires were used to evaluate skin adverse drug reactions and medication literacy. Pearson correlation analysis and binary logistic regression analysis were carried out to identify the correlations between medication literacy and the severity of skin adverse drug reactions in the recruited patients. Results The research sample consisted of 296 patients with a response rate of 92.5%. The mean score of skin adverse drug reactions and the mean score of medication literacy were 1.83 +/- 0.91 and 6.54 +/- 2.78, respectively. In total, 188 patients (63.5%) were considered to have moderate medication literacy. According to the binary logistic regression analysis, the following factors were associated with severe skin adverse drug reactions: age (B = - 3.929, P = 0.000), sex (B = -4.062, P = 0.000), educational level (B = 2.712, P = 0.002), comorbidity (B = 3.297, P = 0.001), eczema history (B = 2.996, P = 0.001), nutritional status (B = -4.891, P = 0.000), blood interleukin-6 level (B = -2.143, P = 0.013), blood high-sensitivity C-reactive protein level (B = -4.015, P = 0.000), combination of drugs (B = -3.183, P = 0.048) and medication literacy (B = - 1.503, P = 0.000). Subgroup analysis showed that in addition to medication literacy, some other factors including education level, comorbidity, nutritional status, blood interleukin-6 level and combined drug application were common factors that contributed to various adverse skin drug reactions in NSCLC patients under targeted EGFR-TKI therapy. Conclusion The low medication literacy of the investigated NSCLC patients undergoing targeted EGFR-TKI therapy was correlated with a high proportion of severe skin adverse drug reactions. In addition, factors other than medication literacy including education level, comorbidity, nutritional status, blood interleukin-6 level and the combinatorial application of drugs were also related to the severity of various adverse skin drug reactions. A comprehensive and targeted intervention may be beneficial to improve medication literacy and control severe skin adverse drug reactions in NSCLC patients.