文献类型：期刊文献

英文题名：Adverse reactions of targeted therapy in cancer patients: a retrospective study of hospital medical data in China

作者：Du, Ruofei[1,2,3];Wang, Xin[1];Ma, Lixia[4];Larcher, Leon M.[5];Tang, Han[1];Zhou, Huiyue[1];Chen, Changying[2];Wang, Tao[1,5,6]

第一作者：Du, Ruofei

通讯作者：Wang, T[1];Chen, CY[2]

机构：[1]Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China;[2]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China;[3]Zhengzhou Univ, Sch Med Sci, Zhengzhou 450001, Peoples R China;[4]Henan Univ Econ & Law, Sch Stat, Zhengzhou 450046, Peoples R China;[5]Murdoch Univ, Ctr Comparat Genom, Perth, WA 6150, Australia;[6]Hebi Peoples Hosp, Hebi 458030, Peoples R China

第一机构：Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China

通讯机构：[1]corresponding author), Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou 450001, Peoples R China;[2]corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.

年份：2021

卷号：21

期号：1

外文期刊名：BMC CANCER

收录：;Scopus(收录号：2-s2.0-85101790820);WOS:【SSCI(收录号:WOS:000622744900001)，SCI-EXPANDED(收录号:WOS:000622744900001)】；

基金：1. The National Natural Science Foundation of China (No.81773175) 2. China Postdoctoral Science Foundation in 2018: (2018 M630839) The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

语种：英文

外文关键词：Adverse reactions; Cancer patients; Hospitalization; Targeted therapy; Quality of life

摘要：Background The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation between ADRs of targeted therapy and treatment effects among cancer patients. This study was to explore the characteristics of ADRs with targeted therapy and the prognosis of cancer patients based on the clinical data. Methods A retrospective secondary data analysis was conducted within an ADR data set including 2703 patients with targeted therapy from three Henan medical centers of China between January 2018 and December 2019. The significance was evaluated with chi-square test between groups with or without ADRs. Univariate and multivariate logistic regression with backward stepwise method were applied to assess the difference of pathological characteristics in patients with cancer. Using the univariate Cox regression method, the actuarial probability of overall survival was performed to compare the clinical outcomes between these two groups. Results A total of 485 patients were enrolled in this study. Of all patients, 61.0% (n = 296) occurred ADRs including skin damage, fatigue, mucosal damage, hypertension and gastrointestinal discomfort as the top 5 complications during the target therapy. And 62.1% of ADRs were mild to moderate, more than half of the ADRs occurred within one month, 68.6% ADRs lasted more than one month. Older patients (P = 0.022) and patients with lower education level (P = 0.036), more than 2 comorbidities (P = 0.021), longer medication time (P = 0.022), drug combination (P = 0.033) and intravenous administration (P = 0.019) were more likely to have ADRs. Those with ADRs were more likely to stop taking (P = 0.000), change (P = 0.000), adjust (P = 0.000), or not take the medicine on time (P = 0.000). The number of patients with recurrence (P = 0.000) and metastasis (P = 0.006) were statistically significant difference between ADRs and non-ADRs group. And the patients were significantly poor prognosis in ADRs groups compared with non-ADRs group. Conclusion The high incidence of ADRs would affect the treatment and prognosis of patients with cancer. We should pay more attention to these ADRs and develop effective management strategies.