文献类型：期刊文献

中文题名：不同运动方式对大鼠肝脏胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3及瘦素受体的影响

英文题名：Effects of exercise mode on IGF-1,IGFBP-3 and leptin receptor expression of liver in rats

作者：邵月[1]

机构：[1]河南省政法管理干部学院体育部

第一机构：河南财经政法大学体育部（系）

年份：2010

期号：17

起止页码：2454-2456

中文期刊名：中国老年学杂志

外文期刊名：Chinese Journal of Gerontology

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(No.30871212);教育部2007年度新世纪人才支持计划(No.790013P8);上海市浦江人才计划(No.44038470);2009年度河南省政治管理干部学院重大课题(No.2009-yzk-020)

语种：中文

中文关键词：运动;IGF-1;IGFBP-3;瘦素受体;大鼠

外文关键词：Exercise; IGF-1; IGFBP-3; Leptin receptor; Rats

摘要：目的探讨不同运动方式对大鼠肝脏胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)和瘦素受体含量的影响。方法 24只大鼠随机分为安静组(C组)、耐力训练组(E组)、高强度间歇性训练组(S组)和悬吊组(D组)4组,每组6只,训练8周;采用Bed-ford训练方案,耐力训练相当于65%VO2max;末次训练后24h各组大鼠安静状态下处死,取肝脏。采用酶联免疫吸附测试(定量)法分别测定肝脏中IGF-1、IGFBP-3和瘦素受体含量。结果 E组IGF-1蛋白含量显著高于C组(P<0.05);S组IGFBP-3蛋白含量极显著高于C组(P<0.01);S组IG-FBP-3/IGF-1比值显著高于E组(P<0.05);E组、S组瘦素受体含量显著高于C组(P<0.05)。结论运动诱导的IGF-1、IGFBP-3和瘦素受体含量变化具有运动方式以及运动强度的敏感性,寻求IGF-1和IGFBP-3之间恰当的比值对于促进人类健康将会有非常重要的意义。
Objective To investigate the effects of exercise mode on the expressions of IGF-1,IGFBP-3 and leptin receptor in rat′s liver.Methods 24 male SD rats were randomly and equally divided into 3 groups：control （C）,endurance exercise （E）,speed exercise （S） and suspending groups（D）.Bedford′s exercise program was adopted in this study,exercise intensity of E was seemly equal to 65% VO2 max.The rats were sampled after 8 weeks exercise training.After the last training 24 h,the rat was killed,the content of IGF-1,IGFBP-3 and leptin receptor in liver were detected by ELISA.Results IGF-1 in E group was higher than that of C group significantly（P〈0.05）.IGFBP-3 in S group was higher than that of C group（P〈0.05）.The ratio of IGF-1/IGFBP-3 was higher than that of E group（P〈0.05）.Content of leptin receptor in E and S groups were higher than that of C group（P〈0.05）.Conclusions Effects of exercise on content of IGF-1,IGFBP-3 and leptin receptor have specificity on exercise mode and sensibility on exercise intensity,the suitable ratio of IGF-1 and IGFBP-3 would be important for human′s health.