文献类型：期刊文献

英文题名：Experience of patients with lung cancer and with targeted therapy-related skin adverse drug reactions: A qualitative study

作者：Du, Ruofei[1,3,7];Yang, Huashan[1];Zhu, Jizhe[1];Zhou, Huiyue[1];Ma, Lixia[2];Getu, Mikiyas Amare[1];Chen, Changying[3];Wang, Tao[1,4,5,6]

第一作者：Du, Ruofei

通讯作者：Wang, T[1];Chen, CY[2];Wang, T[3];Wang, T[4];Wang, T[5]

机构：[1]Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou, Peoples R China;[2]Henan Univ Econ & Law, Sch Stat, Zhengzhou, Peoples R China;[3]Zhengzhou Univ, Affiliated Hosp 1, Dept Qual Control, Zhengzhou, Peoples R China;[4]Telethon Kids Inst, Perth, WA, Australia;[5]Univ Western Australia, Med Sch, Perth, WA, Australia;[6]Peoples Hosp Hebi, Shijiazhuang, Peoples R China;[7]Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China

第一机构：Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou, Peoples R China

通讯机构：[1]corresponding author), Zhengzhou Univ, Coll Nursing & Hlth, Zhengzhou, Peoples R China;[2]corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Qual Control, Zhengzhou, Peoples R China;[3]corresponding author), Telethon Kids Inst, Perth, WA, Australia;[4]corresponding author), Univ Western Australia, Med Sch, Perth, WA, Australia;[5]corresponding author), Peoples Hosp Hebi, Shijiazhuang, Peoples R China.

年份：2022

卷号：9

期号：10

外文期刊名：ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING

收录：;Scopus(收录号：2-s2.0-85139246214);WOS:【SSCI(收录号:WOS:000862687200001)，SCI-EXPANDED(收录号:WOS:000862687200001)】；

基金：This work was supported by the China Postdoctoral Science Foundation in 2018 (Grant No. 2018M630839) and the National Natural Science Foundation of China (Grant No.81773175) .

语种：英文

外文关键词：Non -small -cell lung cancer; Qualitative study; Skin adverse drug reactions; Targeted therapy

摘要：Objective: To explore the experience of non-small-cell lung cancer patients with targeted therapy-related skin adverse drug reactions.Methods: This is a descriptive quantitative study conducted in a comprehensive hospital in Henan, China. Purposive sampling was used to recruit patients with non-small-cell lung cancer and with targeted therapy-related skin adverse drug reactions. In total, 23 patients were approached when the data were saturated. Face-to-face interviews were conducted by an independent researcher using a semi-structured interview guide. Interview data were transcribed and analyzed by qualitative inductive content analysis.Results: Based on the analysis, four main categories were identified according to patients' descriptions of their experience: a lack of self-management ability, psychological and emotional problems, a barrier to social participation, and a need for social support. Suffering from persistent symptoms, insufficient knowledge, skills and strategies for skin adverse drug reaction management, psychological problems, social avoidance/withdrawal, and reduced willingness to work were core experiences that would affect patients' compliance with treatment, prognosis, and the overall quality of life.Conclusions: This study revealed the real experience of patients with non-small-cell lung cancer and with targeted therapy-related skin adverse drug reactions which contributed to the development of targeted interventions to manage skin adverse reactions.